DPC Technology - Overview
DNA-Programmed Chemistry™ ( DPC™) is a patented
method employing DNA to control chemical reactions. Originally developed
by Professor David Liu at
Harvard University, DPC reactions occur between pairs of chemical building
blocks attached to complementary DNA strands. Under mild aqueous conditions,
specific hybridization of the DNA strands brings the building blocks
into close proximity, increasing their relative concentration by a factor
of >10,000. This hybridization also controls reaction stoichiometry
and lowers energies of activation, thus driving highly specific reactions.
The specificity achieved by DPC is analogous to single turnover enzyme
catalysis. Applications of DPC include synthesis of diverse chemical
libraries, discovery of new chemical reactions, and in situ generation
of signal-emitting compounds for use in biodetection applications.
The value of DPC is the ability to program chemical reactions:
- DNA strand sequence identifies every reactant and product
- Hybridization ensures selectivity of reaction
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Reactants (yellow, blue) are brought together by hybridization of associated DNA strands to form product (green).
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To learn more about DPC Technology:
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Program, n:
A series of coded instructions which…automatically direct…a
specific task (Oxford English Dictionary)
The value of DPC lies in the ability to control chemical reactivity
through Programming:
- Every chemical reactant and product is identified by a specific
DNA tag
- DNA hybridization drives chemical reactions and guarantees selectivity
of reaction
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