DNA-Programmed Chemistry™ (DPC™) enables the highly specific control of chemical synthesis. Under mild aqueous reaction conditions, chemical building blocks attached to complementary DNA strands are brought together by specific DNA hybridization events. Such DPC reactions can be run sequentially to make more complex drug-like molecules, and it is possible to make thousands of compounds simultaneously in the same reaction mixture without any chemical cross reactivity.

DPC is very effective at making Ensemblins including those based on macrocycles – molecules with a ring-like circular backbone. The ring closure reaction, which can be challenging under normal synthetic conditions due to competition from unwanted intermolecular reactions, occurs with high fidelity due to the reaction isolation provided by the DNA hybridization.

Ensemble is building a collection of over 100,000 macrocyclic Ensemblins, which we believe is one of the largest such sets of compounds assembled in the pharmaceutical industry. Every compound we generate is purified and is specifically annotated by the presence of the unique DNA tag that dictated the synthesis during the DPC process.

Learn more about:

• Drug Library Synthesis and Library Screening
• Macrocycle Synthesis

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