CD59 (heavy chain of Protectin)(MACIF/1193) , 0.2mg / mL

Reacts with human CD59 , a 20 kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 regulates complement-mediated cell lysis , and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex , whereby it binds complement C8 and/or C9 during the assembly of this complex , thereby inhibiting the incorporation of multiple copies of C9 into the complex , which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC , thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment , that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). It is useful for study on GPI-anchored proteins , PNH and CD59 functions.This antibody is available purified with BSA/azide at 200 ug/ mL , or BSA/azide-free at 1 mg / mL.