ATF4 Antibody HRP conjugated

Volume : 50 µL
Clone Number :
Aliases : Activating transcription factor 4 antibody; ATF 4 antibody; ATF4 antibody; ATF4 protein antibody; ATF4_HUMAN antibody; cAMP-dependent transcription factor ATF-4 antibody; cAMP-responsive element-binding protein 2 antibody; CREB 2 antibody; CREB-2 antibody; CREB2 antibody; Cyclic AMP dependent transcription factor ATF 4 antibody; Cyclic AMP response element binding protein 2 antibody; Cyclic AMP-dependent transcription factor ATF-4 antibody; Cyclic AMP-responsive element-binding protein 2 antibody; DNA binding protein TAXREB67 antibody; DNA-binding protein TAXREB67 antibody; Tax Responsive Enhancer Element B67 antibody; Tax-responsive enhancer element-binding protein 67 antibody; TaxREB67 antibody; TXREB antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P18848
Immunogen : Recombinant Human Cyclic AMP-dependent transcription factor ATF-4 protein (20-200aa)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Transcriptional activator. Binds the cAMP response element (CRE) (consensus : 5\'-GTGACGT[AC][AG]-3\'), a sequence present in many viral and cell µLar promoters. Cooperates with FOXO1 in osteoblasts to reg µLate glucose homeostasis thro µgh suppression of beta-cell production and decrease in ins µLin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Reg µLates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic retic µLum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by reg µLating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Reg µLates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1 possibly in concert with other factors (PubMed : 26086088).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ATF4
Research Areas : Signal Transduction