ATG7 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : 1810013K23Rik antibody; Apg 7 antibody; APG7 autophagy 7 like antibody; APG7 autophagy 7-like (S. cerevisiae) antibody; APG7 like antibody; APG7; S. cerevisiae; homolog of antibody; APG7-like antibody; APG7L antibody; ATG 7 antibody; ATG12-activating enzyme E1 ATG7 antibody; ATG7 antibody; ATG7 autophagy related 7 homolog (S. cerevisiae) antibody; ATG7 autophagy related 7 homolog antibody; ATG7_HUMAN antibody; Atg7l antibody; Autophagy 7; S. cerevisiae; homolog of antibody; Autophagy related protein 7 antibody; Autophagy-related 7 (yeast) antibody; Autophagy-related protein 7 antibody; DKFZp434N0735 antibody; GSA 7 antibody; GSA7 antibody; hAGP7 antibody; Ubiquitin activating enzyme E1 like protein antibody; Ubiquitin-activating enzyme E1-like protein antibody; Ubiquitin-like modifier-activating enzyme ATG7 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O95352
Immunogen : Recombinant Human Ubiquitin-like modifier-activating enzyme ATG7 protein (386-676AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conj µgation with ATG5 as well as the ATG8 family proteins for their conj µgation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to reg µLate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to f µLfill cell µLar energy requirements and preventing excess ROS production. Mod µLates p53/TP53 activity to reg µLate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell gran µLes, as well as in adipose differentiation.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ATG7
Research Areas : Cancer; Cardiovasc µLar; Cell biology; Metabolism; Signal transduction