AR (Ab 650) Antibody

Volume : 100 µL
Clone Number :
Aliases : AIS antibody; ANDR_HUMAN antibody; Androgen nuclear receptor variant 2 antibody; Androgen receptor (dihydrotestosterone receptor; testic µLar feminization; spinal and b µLbar musc µLar atrophy; Kennedy disease) antibody; Androgen receptor antibody; androgen receptor splice variant 4b antibody; AR antibody; AR8 antibody; DHTR antibody; Dihydro testosterone receptor antibody; Dihydrotestosterone receptor (DHTR) antibody; Dihydrotestosterone receptor antibody; HUMARA antibody; HYSP1 antibody; KD antibody; Kennedy disease (KD) antibody; NR3C4 antibody; Nuclear receptor subfamily 3 group C member 4 (NR3C4) antibody; Nuclear receptor subfamily 3 group C member 4 antibody; SBMA antibody; SMAX1 antibody; Spinal and b µLbar musc µLar atrophy (SBMA) antibody; Spinal and b µLbar musc µLar atrophy antibody; Testic µLar Feminization (TFM) antibody; TFM antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P10275
Immunogen : Peptide sequence around aa.648~652 (T-T-S-P-T) derived from Human Androgen Receptor.
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA, WB; WB : 1 : 500-1 : 1000
Background :
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains : the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stim µLates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal b µLbar musc µLar atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Brinkman, A.O. et al. (1999) J. Steroid. Biochem. Mol. Biol. 69, 307-313.
Avila, D.M. et al. (2001) J. Steroid. Biochem. Mol. Biol. 76, 135-142.
Montgomery, J.S. et al. (2001) J. Pathol. 195, 138-146.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conj µgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Conj µgate : Non-conj µgated
Buffer : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form : liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : AR
Research Areas : Epigenetics and Nuclear Signaling;Cancer;Developmental biology;Signal transduction