AXL Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : Adhesion related kinase antibody; AI323647 antibody; Ark antibody; Axl antibody; AXL oncogene antibody; AXL receptor tyrosine kinase antibody; AXL transforming gene antibody; AXL transforming sequence/gene antibody; EC 2.7.10.1 antibody; JTK11 antibody; Oncogene AXL antibody; Tyro7 antibody; Tyrosine protein kinase receptor UFO antibody; Tyrosine-protein kinase receptor UFO antibody; UFO antibody; UFO_HUMAN antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P30530
Immunogen : Recombinant Human Tyrosine-protein kinase receptor UFO protein (312-447AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Receptor tyrosine kinase that transduces signals from the extracell µLar matrix into the cytoplasm by binding growth factor GAS6 and which is thus reg µLating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1 PIK3R2 and PIK3R3; but also GRB2, PLCG1 LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase reg µLatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or reg µLation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : AXL
Research Areas : Cancer; Cell biology; Tags & Cell Markers; Signal transduction