AMFR Antibody FITC conjugated

Volume : 50 µg
Clone Number :
Aliases : AMF receptor antibody; AMF receptor isoform 1 antibody; AMF receptor isoform 2 antibody; AMFR antibody; AMFR2_HUMAN antibody; Autocrine motility factor receptor antibody; Autocrine motility factor receptor precursor; isoform 1 antibody; Autocrine motility factor receptor precursor; isoform 2 antibody; E3 ubiquitin-protein ligase AMFR antibody; gp78 antibody; isoform 2 antibody; RING finger protein 45 antibody; RNF 45 antibody; RNF45 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9UKV5
Immunogen : Recombinant Human E3 ubiquitin-protein ligase AMFR protein (485-643AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic retic µLum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR thro µgh binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also reg µLates ERAD thro µgh the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : AMFR
Research Areas : Cancer; Cell biology