AXIN1 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : AI316800 antibody; AXIN antibody; Axin 1 antibody; Axin-1 antibody; axin1 antibody; AXIN1_HUMAN antibody; Axis inhibition protein 1 antibody; Axis Inhibitor 1 antibody; Fu antibody; fused antibody; Fused; mouse; homolog of antibody; hAxin antibody; Kb antibody; Ki antibody; kinky antibody; knobbly antibody; MGC132911 antibody; MGC52315 antibody; PPP1R49 antibody; Protein Fused antibody; Protein phosphatase 1 reg µLatory subunit 49 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O15169
Immunogen : Recombinant Human Axin-1 protein (418-707AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Component of the beta-catenin destruction complex required for reg µLating CTNNB1 levels thro µgh phosphorylation and ubiquitination, and mod µLating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-reg µLates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon µLtraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : AXIN1
Research Areas : Cell biology; Tags & Cell Markers; Signal transduction; Stem cells